Study identifies test for high levels of vinculin antibodies in patients with irritable bowel syndrome
For the first time, a simple blood test may be the best way to determine if a patient is suffering from Irritable Bowel Syndrome (IBS), or another serious condition such as Inflammatory Bowel Disease (IBD,) according to Cedars-Sinai physician researcher Mark Pimentel, MD, lead author of a multicenter clinical trial.
Researchers conclusively identified a test for antibodies that form against a particular protein, vinculin, found in the guts of patients, many of whom suffered acute gastroenteritis at some point.
“This is a major breakthrough. It is the first test with a high specificity for IBS, likely based on a pathological mechanism of the disease,” said Pimentel, the director of the Cedars-Sinai GI Motility Program and the GI Motility Laboratory. Pimentel is co-author of the study and results were presented for the first time this week at the American College of Gastroenterology’s 78th Annual Scientific Meeting in San Diego, Calif.
In the study, 221 patients were evaluated; some had a diagnosis of IBS, some were diagnosed with IBD and some were healthy, with no symptoms. Anti-vinculin antibodies were significantly elevated in IBS patients as compared to those with IBD or those who were healthy. …