Migraine Linked to Irritable Bowel Syndrome
Our results suggest a high possibility of phenotypic and genotypic associations between IBS and primary headache disorders (particularly migraine) and support the presence of some shared pathophysiology, Derya Uluduz, MD, from Istanbul University in Turkey, told Medscape Medical News.
“Greater attention should be focused on the comorbidities of these conditions and their potential contribution to better understanding and managing the disorder. Physicians should examine the presence of IBS in migraine and tension-type headache patients or vice versa for accurate management of these disorders,” Dr Uluduz added.
The study was released February 23 ahead of presentation in April at the American Academy of Neurology 68th Annual Meeting in Vancouver, Canada.
“Migraine of the Bowels”
“In designing this study, we were interested in whether IBS and migraine coexist within a same spectrum of central sensitization syndrome and have phenotypic and genotypic associations,” Dr Uluduz explained. “We already knew that brain plays significant role in IBS. IBS may be characterized by dysfunctions in processing of information by the central nervous system. IBS patients have increased hypothalamic activity suggesting an association among IBS, stress and hypothalamic axis. In this respect, IBS may be defined as the ‘migraine of the bowels.'”
The study included 107 people with migraine, 53 with episodic tension-type headache (ETTH), 107 with IBS, and 53 healthy individuals. “This is the first study to investigate the relationship between IBS and primary headaches, including ETTH, using a comprehensive face-to-face clinical diagnostic evaluation and information on multiple serotonin transporter gene polymorphisms,” Dr Uluduz told Medscape Medical News.
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