Loading…
Crohns Disease Affects Brain Function

Crohns Disease Affects Brain Function

Crohns Disease Affects Brain Function, A new research has found that Crohn’s disease not only affects the gut but also has an impact on the brain. Crohn’s disease is a chronic inflammatory bowel disease characterized by inflammation of the digestive, or gastrointestinal, tract.

The research published in the UEG Journal on Wednesday shows that those with Crohns disease experience slower response times compared with individuals who do not have the disease. The cognitive response times were 10 percent slower than normal and significantly corresponded with symptoms of active inflammation, including abdominal pain and fatigue, the study finds. The results show the presence of a mild cognitive impairment in Crohn’s patients. This also supports frequent complaints from patients related to lack of concentration, clouding of thought and memory lapses. The study also found that Crohn’s patients had a higher median depression score and a poorer rate of sleep quality.

“These results reinforce the notion that Crohn’s has a wide range of multi-systemic consequences with the impact of the disease affecting patients not only within but well beyond the digestive tract,” Dr. Daniel van Langenberg, the lead researcher of the study, said in a statement. “The findings appear consistent with experiments that have shown that bowel inflammation results in an upregulation of inflammatory hippocampus activity in the brain. This, in turn, might account for the slower response times that were observed in the study.”

Crohn’s disease, which is one of the two main forms of inflammatory bowel disease, can cause abdominal pain, diarrhea, weight loss, anemia, and fatigue. There is no cure for Crohn’s disease but medications such as steroids and immunosuppressants can be used to slow the progression of the disease.

Commenting on the research, Gigi Veereman, UEG inflammatory bowel disease expert, said: “This research highlights the need for regular interventions with multi-disciplinary IBD teams to address the wide issues that are presented with Crohn’s disease. This will enable a greater understanding of this complex condition and therefore improve the service and care offered to each patient.”

Read More: Crohn’s Disease Symptoms Update: Inflammatory Bowel Disease Affects Brain Function

 
Takeda says Ka Pow IBD

Takeda says Ka Pow IBD

Takeda worked with the Crohn’s and Colitis Foundation of America and Marvel Custom Solutions to create its first-ever pharma company-sponsored superhero to shine a light on the many sufferers of IBD who hide their disease. The disease awareness campaign includes the graphic illustration series with IBD-suffering hero Samarium, as well as digital paid ads and social media shares.

Stephanie Brown, VP of Takeda’s specialty business unit in the U.S., said in a statement that “our hope is that patients will feel inspired to have the raw and real conversations they need to have with healthcare professionals, family, and friends, to increase awareness, understanding, and to strive for the best care for their IBD.”

The first-in-the-series online comic, out now, will be made into actual comic books and distributed at some events, including several Comic-Con festivals that Takeda will attend, a Takeda spokeswoman told FiercePharmaMarketing. She said more stories are planned for the graphic illustration series, including global editions. And for every view of the online graphic at IBDUnmasked.com, Takeda will donate $1 to CCFA, up to $25,000.

Takeda markets IBD biologic Entyvio, although that brand is not mentioned in this disease awareness campaign. Entyvio, which did launch a branded ad campaign earlier this year, faces competition in a crowded IBD space where it’s up against established Crohn’s and ulcerative colitis brands such as AbbVie’s Humira, Amgen’s Enbrel, and Johnson & Johnson’s Remicade and follow-up Simponi.

Takeda marketers were introduced to Marvel through a mutual agency partner. The ideas for the graphic were then generated in an all-day brainstorming session that included Takeda and CCFA representatives, along with patients who have Crohn’s disease or ulcerative colitis.

The initial response has been “incredibly positive” from patients, the spokeswoman said, pointing out that “even when you work in a heavily regulated environment, you can still be creative and create something interesting and compelling enough for people to want to share it.”

Takeda’s press release

 
Environment impact on health

Environment impact on health

Toronto researchers to investigate environment’s impact on healthFour researchers at the University of Toronto and its affiliated research centres are receiving $2-million each to investigate how environmental factors can impact health. The funding from the Canadian Institutes of Health Research was announced today by federal health minister, the Honourable Jane Philpott.

“This research funding will enable researchers to use these new technologies to better understand the complex interactions that cause chronic disease, and ultimately help us to identify better ways to prevent and treat chronic disease conditions,” said Dr. Philip Sherman, Scientific Director of the CIHR Institute of Nutrition, Metabolism and Diabetes.

Those funds will help Professor Jennifer Gommerman investigate autoimmune disease in South Asian Canadians. As she explains, the project will provide insight on how a change in one’s environmental setting can impact health.

“Immigration often transplants individuals and families into radically different environments in terms of climate, prevailing diet, exposure to microbial pathogens, exposure to pollutants, and changes in lifestyle dictated by economic necessity; yet, we know little about the impact of global migration on health and disease,” says Gommerman, an immunology professor.

This work will help patients like Rasheed Clarke who suffers from ulcerative colitis.

“My parents are both from India and I still have family who live there. I was born in Canada and developed ulcerative colitis. There was never a case of inflammatory bowel disease in my family. So I wonder, what is it about the environment here that triggered UC in me? I have the feeling that I wouldn’t have developed colitis if I was born and raised in India, but I don’t know that for sure, which is why this research is so important,” said Clarke.

This research is also being supported by Crohn’s and Colitis Canada.

“Canada has among the highest rates of inflammatory bowel disease (IBD) in the world. Increasingly we are seeing families new to Canada developing IBD for the first time” says Mina Mawani, President and CEO, Crohn’s and Colitis Canada. “This research will shed new light as to how our Canadian environment and diet contribute to the development of Crohn’s disease and ulcerative colitis, and brings us closer to new ways to prevent and treat these diseases affecting nearly 250,000 Canadians.”

The other projects supported by today’s announcement are:

Immunology Professor Alberto Martin will investigate the impact gut microbiome and the environment can contribute to the development of colorectal cancer, which is the second leading cause of cancer-related deaths in Canada.

Read more: Environment impact on health