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Inflammatory Marker Genome

New Inflammatory Marker Genome

New links between the human genome and inflammation tracers have been found by researchers in Finland. In a study of over ten million DNA variations, new possibilities for treatment of diseases such as multiple sclerosis, Crohn’s disease and celiac disease were uncovered.

Researchers at the Research Centre of Applied and Preventive Cardiovascular Medicine at the University of Turku, Finland noticed that the medicine daclizumab, previously used for treating organ rejection reactions, could possibly also be used in the treatment of multiple sclerosis and Crohn’s disease.

In addition, an increase in the activity of MIP1b-cytokine could also serve as a method of treatment against celiac disease and Behcet’s disease. Further clinical studies are required to confirm the observations.

Read More: New Inflammatory Marker Genome

 
Crohns disease

Crohns disease changed me at 23

A friend once told me, “You’re invincible when you’re 23.” A thought I shrugged off at the time, but it came rushing back when, weeks after my 23rd birthday, I became sick and then sicker.

It started as the flu, but by Valentine’s Day I was admitted to Texas Health Presbyterian Hospital Dallas with abdominal pain, a 103-degree fever, diarrhea, no appetite and a skyrocketing white blood cell count.

A few days later, my dad, who had flown from Kansas, and a nurse were persuading me to force the bitter lemon taste of magnesium citrate down my throat to prepare for my first colonoscopy.

The anesthesiologist told me that I would be put to sleep using Propofol. “It’s what killed Michael Jackson, but we’ll take good care of you.”

Results came back, but they were nonspecific. “Get rest. You’ll be better in a week or two.”

I lay in bed. I slept. I did not eat. I was too tired to watch Netflix.

A couple of weeks later, I was back in line at the Presby emergency room. Again I struggled to keep down the magnesium citrate that would cleanse my intestines. And again my dad kept watch over me from a cot at the foot of the bed.

“You have Crohn’s disease,” said my gastroenterologist as he scanned the room for a reaction.

“It is an autoimmune disease,” he said. “There is no known cure.”

Crohn’s disease may affect as many as 700,000 Americans, according to the Crohn’s and Colitis Foundation of America.

Researchers think it is genetic, though no one else in my family has been diagnosed. It is caused by an increase in TNF proteins in the immune system. The body’s ramped-up immune system attacks the GI system, just like it would attack an infection. This leads to high fevers, diarrhea, inflammation and ulcers. The ulcers can eat through the intestinal wall and cause your abdominal cavity to become septic.

Read More: How a diagnosis of Crohn’s disease changed me at 23

 

Bad diet and no sun blamed for rise in Crohns disease

there has been a massive 750 per cent rise in the number of under-16s being diagnosed with Crohn’s disease in Scotland in the past 45 years. New research by Scottish medical researchers also shows a 33 per cent increase in the number of children developing inflammatory bowel disease (PIBD) which includes Crohn’s and ulcerative colitis in the past five years.

Experts warn that an increase in processed food, a lack of vitamin D and antibiotic over-prescribing could all be contributing to the rapid rise.

Scotland has one of the highest PIBD rates worldwide and the highest in the UK.

Crohn’s disease is an incurable illness, causing inflammation, ulcers and scarring. Main symptoms are bowel pain, diarrhoea, tiredness and weight loss, and it is often associated with other inflammatory conditions affecting the joints, skin and eyes.

Read More: Bad diet and no sun blamed for rise in Crohns disease