Crohns Disease Affects Brain Function

Crohns Disease Affects Brain Function

Crohns Disease Affects Brain Function, A new research has found that Crohn’s disease not only affects the gut but also has an impact on the brain. Crohn’s disease is a chronic inflammatory bowel disease characterized by inflammation of the digestive, or gastrointestinal, tract.

The research published in the UEG Journal on Wednesday shows that those with Crohns disease experience slower response times compared with individuals who do not have the disease. The cognitive response times were 10 percent slower than normal and significantly corresponded with symptoms of active inflammation, including abdominal pain and fatigue, the study finds. The results show the presence of a mild cognitive impairment in Crohn’s patients. This also supports frequent complaints from patients related to lack of concentration, clouding of thought and memory lapses. The study also found that Crohn’s patients had a higher median depression score and a poorer rate of sleep quality.

“These results reinforce the notion that Crohn’s has a wide range of multi-systemic consequences with the impact of the disease affecting patients not only within but well beyond the digestive tract,” Dr. Daniel van Langenberg, the lead researcher of the study, said in a statement. “The findings appear consistent with experiments that have shown that bowel inflammation results in an upregulation of inflammatory hippocampus activity in the brain. This, in turn, might account for the slower response times that were observed in the study.”

Crohn’s disease, which is one of the two main forms of inflammatory bowel disease, can cause abdominal pain, diarrhea, weight loss, anemia, and fatigue. There is no cure for Crohn’s disease but medications such as steroids and immunosuppressants can be used to slow the progression of the disease.

Commenting on the research, Gigi Veereman, UEG inflammatory bowel disease expert, said: “This research highlights the need for regular interventions with multi-disciplinary IBD teams to address the wide issues that are presented with Crohn’s disease. This will enable a greater understanding of this complex condition and therefore improve the service and care offered to each patient.”

Read More: Crohn’s Disease Symptoms Update: Inflammatory Bowel Disease Affects Brain Function

Takeda says Ka Pow IBD

Takeda says Ka Pow IBD

Takeda worked with the Crohn’s and Colitis Foundation of America and Marvel Custom Solutions to create its first-ever pharma company-sponsored superhero to shine a light on the many sufferers of IBD who hide their disease. The disease awareness campaign includes the graphic illustration series with IBD-suffering hero Samarium, as well as digital paid ads and social media shares.

Stephanie Brown, VP of Takeda’s specialty business unit in the U.S., said in a statement that “our hope is that patients will feel inspired to have the raw and real conversations they need to have with healthcare professionals, family, and friends, to increase awareness, understanding, and to strive for the best care for their IBD.”

The first-in-the-series online comic, out now, will be made into actual comic books and distributed at some events, including several Comic-Con festivals that Takeda will attend, a Takeda spokeswoman told FiercePharmaMarketing. She said more stories are planned for the graphic illustration series, including global editions. And for every view of the online graphic at IBDUnmasked.com, Takeda will donate $1 to CCFA, up to $25,000.

Takeda markets IBD biologic Entyvio, although that brand is not mentioned in this disease awareness campaign. Entyvio, which did launch a branded ad campaign earlier this year, faces competition in a crowded IBD space where it’s up against established Crohn’s and ulcerative colitis brands such as AbbVie’s Humira, Amgen’s Enbrel, and Johnson & Johnson’s Remicade and follow-up Simponi.

Takeda marketers were introduced to Marvel through a mutual agency partner. The ideas for the graphic were then generated in an all-day brainstorming session that included Takeda and CCFA representatives, along with patients who have Crohn’s disease or ulcerative colitis.

The initial response has been “incredibly positive” from patients, the spokeswoman said, pointing out that “even when you work in a heavily regulated environment, you can still be creative and create something interesting and compelling enough for people to want to share it.”

Takeda’s press release

Crohns disease

Crohns disease changed me at 23

A friend once told me, “You’re invincible when you’re 23.” A thought I shrugged off at the time, but it came rushing back when, weeks after my 23rd birthday, I became sick and then sicker.

It started as the flu, but by Valentine’s Day I was admitted to Texas Health Presbyterian Hospital Dallas with abdominal pain, a 103-degree fever, diarrhea, no appetite and a skyrocketing white blood cell count.

A few days later, my dad, who had flown from Kansas, and a nurse were persuading me to force the bitter lemon taste of magnesium citrate down my throat to prepare for my first colonoscopy.

The anesthesiologist told me that I would be put to sleep using Propofol. “It’s what killed Michael Jackson, but we’ll take good care of you.”

Results came back, but they were nonspecific. “Get rest. You’ll be better in a week or two.”

I lay in bed. I slept. I did not eat. I was too tired to watch Netflix.

A couple of weeks later, I was back in line at the Presby emergency room. Again I struggled to keep down the magnesium citrate that would cleanse my intestines. And again my dad kept watch over me from a cot at the foot of the bed.

“You have Crohn’s disease,” said my gastroenterologist as he scanned the room for a reaction.

“It is an autoimmune disease,” he said. “There is no known cure.”

Crohn’s disease may affect as many as 700,000 Americans, according to the Crohn’s and Colitis Foundation of America.

Researchers think it is genetic, though no one else in my family has been diagnosed. It is caused by an increase in TNF proteins in the immune system. The body’s ramped-up immune system attacks the GI system, just like it would attack an infection. This leads to high fevers, diarrhea, inflammation and ulcers. The ulcers can eat through the intestinal wall and cause your abdominal cavity to become septic.

Read More: How a diagnosis of Crohn’s disease changed me at 23