Thomas Exler

Thomas Exler Story

I was born with a rare birth defect called bladder exstrophy, meaning that my bladder was turned inside out. In 1969, just before my fourth birthday, I had urostomy surgery.

As a child with an ostomy, my life could easily have been one of isolation and shame. But my family was committed to treating me like any other child. This would prove to be the motivation for and the foundation of a life dedicated to helping others overcome their own challenges.

Shortly after my ostomy surgery, my mother and my surgeon founded the Children’s Tri-State Ostomy Association (Pennsylvania, Ohio and West Virginia), the first organization in the world dedicated to helping parents of children with an ostomy. I was closely involved in this organization and grew up surrounded by other children facing serious health issues. This inspired me and taught me compassion. It also prevented me from asking, “Am I alone?” I knew there were many people just like me.

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Inflammatory Marker Genome

New Inflammatory Marker Genome

New links between the human genome and inflammation tracers have been found by researchers in Finland. In a study of over ten million DNA variations, new possibilities for treatment of diseases such as multiple sclerosis, Crohn’s disease and celiac disease were uncovered.

Researchers at the Research Centre of Applied and Preventive Cardiovascular Medicine at the University of Turku, Finland noticed that the medicine daclizumab, previously used for treating organ rejection reactions, could possibly also be used in the treatment of multiple sclerosis and Crohn’s disease.

In addition, an increase in the activity of MIP1b-cytokine could also serve as a method of treatment against celiac disease and Behcet’s disease. Further clinical studies are required to confirm the observations.

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Migraine Linked to Irritable Bowel Syndrome

Migraine Linked to Irritable Bowel Syndrome

Migraine Linked to Irritable Bowel Syndrome

Our results suggest a high possibility of phenotypic and genotypic associations between IBS and primary headache disorders (particularly migraine) and support the presence of some shared pathophysiology, Derya Uluduz, MD, from Istanbul University in Turkey, told Medscape Medical News.

“Greater attention should be focused on the comorbidities of these conditions and their potential contribution to better understanding and managing the disorder. Physicians should examine the presence of IBS in migraine and tension-type headache patients or vice versa for accurate management of these disorders,” Dr Uluduz added.

Migraine Linked to Irritable Bowel Syndrome
Migraine Linked to Irritable Bowel Syndrome

The study was released February 23 ahead of presentation in April at the American Academy of Neurology 68th Annual Meeting in Vancouver, Canada.

“Migraine of the Bowels”

“In designing this study, we were interested in whether IBS and migraine coexist within a same spectrum of central sensitization syndrome and have phenotypic and genotypic associations,” Dr Uluduz explained. “We already knew that brain plays significant role in IBS. IBS may be characterized by dysfunctions in processing of information by the central nervous system. IBS patients have increased hypothalamic activity suggesting an association among IBS, stress and hypothalamic axis. In this respect, IBS may be defined as the ‘migraine of the bowels.'”

The study included 107 people with migraine, 53 with episodic tension-type headache (ETTH), 107 with IBS, and 53 healthy individuals. “This is the first study to investigate the relationship between IBS and primary headaches, including ETTH, using a comprehensive face-to-face clinical diagnostic evaluation and information on multiple serotonin transporter gene polymorphisms,” Dr Uluduz told Medscape Medical News.

Read More: Migraine Linked to Irritable Bowel Syndrome